Overactivated epithelial NF-κB disrupts lung development in human and nitrofen CDH
Florentine Dylong, Jan Riedel, Gaurang M. Amonkar, Nicole Peukert, Paula Lieckfeldt, Katinka Sturm, Benedikt Höxter, Wai Hei Tse, Yuichiro Miyake, Steffi Mayer, Richard Keijzer, Martin Lacher, Xingbin Ai, Jan‐Hendrik Gosemann, Richard Wagner
This study shows that overactivated NF-κB disrupts lung development in CDH and that dexamethasone or curcumenol can rescue lung hypoplasia by normalizing NF-κB signaling.
bioRxiv · Apr 7, 2023 · PreprintDevelopmental Biology