Richard Keijzer

Dysregulated circRNA expression profile and associated miRNA sponging in abnormal lung development in congenital diaphragmatic hernia

The paper identifies a unique circRNA signature in congenital diaphragmatic hernia (CDH) lung development, showing miRNA sponging effects and pathway overlaps between rat and human CDH.

FindBacksplice: a Tool for Locating Circular RNA Backsplice Coordinates

FindBacksplice locates circular RNA backsplice coordinates using BSJ sequences across any genome version and species.

Overactivated epithelial NF-κB disrupts lung development in human and nitrofen CDH

This study shows that overactivated NF-κB disrupts lung development in CDH and that dexamethasone or curcumenol can rescue lung hypoplasia by normalizing NF-κB signaling.

A tracheal aspirate-derived airway basal cell model reveals a pro-inflammatory epithelial defect in congenital diaphragmatic hernia

This study develops a human airway basal cell model from tracheal aspirates to investigate epithelial defects in congenital diaphragmatic hernia, finding a pro-inflammatory signature and therapeutic response to steroids.

Proteomic Profiling of Hypoplastic Lungs Suggests an Underlying Inflammatory Response in the Pathogenesis of Abnormal Lung Development in Congenital Diaphragmatic Hernia

The paper uses proteomic profiling to identify inflammatory processes as a key factor in the pathogenesis of lung hypoplasia in congenital diaphragmatic hernia.