Richard Wagner

The paper identifies a unique circRNA signature in congenital diaphragmatic hernia (CDH) lung development, showing miRNA sponging effects and pathway overlaps between rat and human CDH.

The paper identifies missense variants in PLS3 causing X-linked congenital diaphragmatic hernia and body wall defects through genetic analysis and functional studies.

This study shows that overactivated NF-κB disrupts lung development in CDH and that dexamethasone or curcumenol can rescue lung hypoplasia by normalizing NF-κB signaling.

This study develops a human airway basal cell model from tracheal aspirates to investigate epithelial defects in congenital diaphragmatic hernia, finding a pro-inflammatory signature and therapeutic response to steroids.

Amniotic fluid stem cell extracellular vesicles improve fetal lung development in CDH by modulating macrophage inflammation and restoring normal gene expression.

The paper uses proteomic profiling to identify inflammatory processes as a key factor in the pathogenesis of lung hypoplasia in congenital diaphragmatic hernia.