Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis
Ram Prasad Naikawadi, Alexey V. Bazarov, Michael Wax, Kaveh Boostanpour, Jasleen Kukreja, Michela Traglia, Ayushi Agrawal, Reuben Thomas, Mallar Bhattacharya, Paul J. Wolters
The paper identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis using single-cell RNA sequencing and shows that p53 inhibition can reverse fibrosis.
American Journal of Respiratory and Critical Care Medicine · Feb 4, 2026Peer-reviewedCell Biology