Michela Traglia

Branched-chain amino acid fermentation as an alternative mammalian electron sink

This study identifies branched-chain amino acid fermentation as an alternative electron sink in mammals under hypoxia, with implications for reductive stress and sperm motility.

Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID

This study uses multiomic and spatial profiling of colorectal tissue and blood to show that Long COVID is linked to immune dysregulation and viral persistence, with stronger signals in tissue than blood.

Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease

This study shows that blocking fibrin-induced microglia activation reduces neuronal hyperactivity and restores the neuroimmune interactome in Alzheimer's disease.

Immune activation during broadly neutralizing antibody-mediated HIV suppression prior to post-intervention control

This study shows that bNAb-mediated HIV suppression is linked to increased immune activation compared to ART suppression, with unique transcriptional patterns in controllers.

Structural variants in human congenital heart disease disrupt distal genomic regulatory contacts of developmental genes

The paper develops a machine-learning model to predict how structural variants disrupt 3D chromatin structure in congenital heart disease and validates its predictions using induced pluripotent stem cells.

Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis

The paper identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis using single-cell RNA sequencing and shows that p53 inhibition can reverse fibrosis.

Genetic survey of biomarkers across pregnancy identifies pregnancy-specialized immune regulation

The paper conducts a genetic analysis of immune biomarkers across pregnancy timepoints, identifying heritable and genome-wide significant associations and highlighting timepoint-specific and pregnancy-unique findings.

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

The paper examines sex-differentiated genetic effects across neuropsychiatric and behavioral traits using GWAS summary statistics and finds small, polygenic sex differences with enriched neuron-related genes.

cis-Regulatory Chromatin Contacts in Neural Cells Reveal Contributions of Genetic Variants to Complex Neurological Disorders

The paper identifies cis-regulatory chromatin contacts in neural cells and links them to genetic variants associated with complex neurological disorders.

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

This study identifies 6 new blood pressure loci and 48 genes involved in BP regulation using GWAS and gene expression data from blood and kidney tissues.

Purging of deleterious variants due to drift and founder effect in Italian populations with extended autozygosity

The paper analyzes whole-genome sequencing data from Italian founder populations to determine the cause of purging of deleterious variants, concluding that genetic drift and founder effect, not consanguinity, are responsible.