Stephanie A. Christenson

This study identifies allergen-reactive Th2 cells in human airways using high-dimensional profiling and shows their systemic expansion following allergen challenge.

The paper analyzes expression and splicing quantitative trait loci (e/sQTL) across multiple tissues in the TOPMed dataset and finds that secondary e/sQTL signals are still discoverable, with many GWAS signals colocalizing with these e/sQTL.

This study identifies genetic variants associated with sputum mucin concentrations and links one variant to COPD phenotypes like chronic bronchitis and acute exacerbations.

The paper identifies molecular and structural changes in aging human lungs that contribute to fibrosis and impair lung function.

This paper develops a metagenomic sequencing approach to diagnose lower respiratory tract infections by integrating pathogen detection, microbiome analysis, and host transcriptome data.

This paper introduces ROP to identify the source of unmapped RNA-Seq reads across diverse tissues, showing it can account for 99.9% of 1 trillion reads and reveals immune and microbial correlations.

This study uses metagenomic sequencing to detect respiratory pathogens in hematopoietic transplant patients, finding it more sensitive than conventional methods and identifying new pathogens.