Molecular evidence of widespread benzimidazole drug resistance in Ancylostoma caninum from domestic dogs throughout the USA and discovery of a novel isotype-1 β-tubulin benzimidazole resistance mutation.
Abhinaya Venkatesan, Pablo David Jimenez Castro, Arianna Morosetti, Hannah Horvath, Rebecca Chen, Elizabeth Redman, Kayla Dunn, James Bryant Collins, James S. Fraser, Erik C. Andersen, Ray M. Kaplan, John S. Gilleard
This paper identifies widespread benzimidazole resistance in Ancylostoma caninum from dogs across the USA, including a novel β-tubulin mutation and confirms its functional significance.
bioRxiv · Oct 12, 2022 · PreprintGenomics