Erik C. Andersen

The paper updates a toolkit for genetic studies in C. briggsae by identifying indel variants and mapping mutations to genes using high-throughput sequencing.

The paper applies a selfing-aware demographic inference method to Hawaiian C. elegans populations, revealing population structure, bottlenecks, and the impact of self-fertilization on demographic estimates.

The paper analyzes the genomic diversity of C. tropicalis, finding geographic correlation and hyper-divergent regions linked to environmental adaptation.

NemaSize is an AI pipeline that accurately measures nematode body size across complex postures, outperforming CellProfiler in curved and overlapping animals.

This study shows that a male-expressed mating plug in nematodes increases female fertility by extending reproductive windows and reducing sperm loss, indicating reproductive cooperation rather than male competition.

The paper presents a gap-free, telomere-to-telomere genome assembly for the C. briggsae AF16 strain, along with improved gene annotations and variant mappings.

The paper identifies beta-tubulin variants associated with benzimidazole resistance in three Caenorhabditis species and shows species-specific patterns of resistance.

This study tracks mutation rates and fitness effects in C. elegans under minimal selection, finding increased indel mutation rates and no change in nucleotide substitution rates.

The paper identifies 94 candidate genes in C. elegans linked to susceptibility to 23 environmental toxicants using genome-wide association analysis.

The paper tracks mutation accumulation in natural C. elegans populations over time, finding a substitution rate and spatio-temporal dispersal patterns.

The paper analyzes over 2,000 Caenorhabditis briggsae wild strains to uncover genetic diversity, population structure, and evolutionary mechanisms shaping phenotypic variation.

The paper develops a high-throughput assay to measure cold tolerance in C. elegans and finds that 24-hour cold exposure increases variation and heritability of cold tolerance during the L1 larval stage.

This study tests fenbendazole efficacy against ascarid parasites in poultry, finding resistance in one Ascaridia galli isolate and all Heterakis gallinarum isolates.

This paper develops a mesh filter-based technique to isolate C. elegans embryos for synchronization, achieving higher yield and better downstream development than bleach methods.

This paper identifies a cytochrome P450 gene variant that contributes to benzimidazole resistance in nematodes, independent of beta-tubulin mutations.

The paper identifies transposon-mediated structural variations at the eri-6/7 locus in C. elegans that affect gene expression and siRNA pathway function.

This study infers the distribution of fitness effects of mutations in C. elegans using recombinant inbred lines, finding that positive effects are common but LD can skew results.

This study identifies genetic variants affecting alcohol sensitivity in C. elegans, highlighting a potential druggable target for alcohol use disorders.

This study quantifies the fitness effects of resistance alleles to albendazole and ivermectin in C. elegans, finding that resistance requires specific gene deletions and that multi-drug resistance is not observed.

The paper tests the role of five beta-tubulin genes in benzimidazole resistance in C. elegans, finding that only ben-1 loss confers substantial resistance.

The paper discovers a pro-nematicide scaffold, Cyprocide, that selectively kills diverse plant-parasitic nematodes through P450 enzyme activation, offering a potential solution for sustainable nematode management.

The paper identifies genetic variants in gap-2 that modify daf-7 expression and influence exploratory foraging behavior in C. elegans.

This study investigates praziquantel's effects on C. elegans development and identifies potential genetic factors, including cct-8, that influence susceptibility.

The paper improves gene models for the C. briggsae QX1410 genome through manual curation, achieving quality comparable to the well-curated AF16 strain.

This study identifies genetic differences among C. elegans strains that drive variation in anthelmintic responses across multiple drug classes, highlighting the importance of genetic diversity in understanding anthelmintic resistance.

The paper benchmarks structural variant prediction tools in C. elegans, showing performance varies by variant type and sequencing depth, and highlights the need for real-data reference datasets.

The paper introduces an experimental design with anchor strains to reduce batch effects in metabolomics, enabling integration of NMR and LC-MS data across studies.

The paper identifies that neuronal ben-1 function is critical for benzimidazole susceptibility in C. elegans, with cholinergic neurons playing a key role.

This paper identifies widespread benzimidazole resistance in Ancylostoma caninum from dogs across the USA, including a novel β-tubulin mutation and confirms its functional significance.

The paper characterizes STR variation across 540 wild C. elegans strains, finding more contractions than expansions and selection effects on STR mutations.