ER O-glycosylation in synovial fibroblasts drives cartilage degradation
Le Son Tran, Joanne Chia, Xavier Le Guezennec, Keit Min Tham, Anh Tuan Nguyen, Virginie Sandrin, Way Cherng Chen, Tan Tong Leng, Sreedharan Sechachalam, Khai Pang Leong, Frédéric Bard
This study identifies ER O-glycosylation by GALNTs in synovial fibroblasts as a driver of cartilage degradation in arthritis, with Calnexin as a potential therapeutic target.
Nature Communications · Mar 14, 2025Peer-reviewedCell Biology