Author

Xavier Le Guezennec

Agency for Science, Technology and ResearchORCID 0000-0002-1590-1325Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Frédéric BardiD· 2 shared Alex ChauviniD· 1 shared Anh Tuan NguyeniD· 1 shared Brice ChaneziD· 1 shared Eric MasiD· 1 shared Eugénie Lohmann· 1 shared Fabienne GuillaumondiD· 1 shared Giacomo Del RioiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Frédéric BardORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 8, 2026

Co-translational O-glycosylation driven by GALNTs spatial reprogramming fosters pancreatic cancer growth

Rebecca Bennion, Eugénie Lohmann, Giacomo Del Rio…·Frédéric Bard

The paper shows that GALA, a process relocating GALNTs to the ER, enables co-translational O-glycosylation in pancreatic cancer, expanding the O-glycoproteome and promoting tumor growth.

DOI 10.64898/2026.09.04.749345

mousehuman

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Cell BiologyNature CommunicationsPeer-reviewedMar 14, 2025

ER O-glycosylation in synovial fibroblasts drives cartilage degradation

Le Son Tran, Joanne Chia, Xavier Le Guezennec…·Frédéric Bard

This study identifies ER O-glycosylation by GALNTs in synovial fibroblasts as a driver of cartilage degradation in arthritis, with Calnexin as a potential therapeutic target.

17 citationstop 4%

humanmouse

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