Faithful Modeling of Terminal CD8 T Cell Dysfunction and Epigenetic Stabilization In Vitro
Amir Yousif, Abbey A. Saadey, Ava M. Lowin, Asmaa M. Yousif, Ankita Saini, Madeline R. Allison, Kelley Ptak, Eugene M. Oltz, Hazem E. Ghoneim
This study develops an in vitro model of terminal CD8 T cell dysfunction and epigenetic stabilization, revealing stable exhaustion signatures and impaired functionality.
JCI Insight · Oct 7, 2025Peer-reviewedImmunology