Author

Amir Yousif

The Ohio State UniversityORCID 0000-0002-7300-1667Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Hazem E. GhoneimiD· 2 shared Abbey A. SaadeyiD· 1 shared Adam D. KenneyiD· 1 shared Amal O. AmeriD· 1 shared Amy WebbiD· 1 shared Andrew J. McNamaraiD· 1 shared Ankita SainiiD· 1 shared Asmaa BadriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Hazem E. GhoneimORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection

Mostafa M. Eltobgy, Mohamed M. Shamseldin, Owen D. Whitham, Heba M. Amer, Jeffrey Atkinson, Asmaa Badr, Jesse M. Hall, Gauruv A. Gupta, Yara Y. Hassan, Rabab ElMergawy, Richard Perez, Sarah E. Faber, Maciej Pietrzak, Amy Webb, Xiaoli Zhang, , Amal O. Amer

This study shows that Caspase-11 worsens severe SARS-CoV-2 by increasing inflammation and reducing CD8 T-cell immunity, but its removal improves viral clearance and survival.

JCI Insight · Sep 21, 2026Peer-reviewedMicrobiology

Faithful Modeling of Terminal CD8 T Cell Dysfunction and Epigenetic Stabilization In Vitro

Amir Yousif, Abbey A. Saadey, Ava M. Lowin, Asmaa M. Yousif, Ankita Saini, Madeline R. Allison, Kelley Ptak, Eugene M. Oltz, Hazem E. Ghoneim

This study develops an in vitro model of terminal CD8 T cell dysfunction and epigenetic stabilization, revealing stable exhaustion signatures and impaired functionality.

JCI Insight · Oct 7, 2025Peer-reviewedImmunology