Hazem E. Ghoneim

Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection

This study shows that Caspase-11 worsens severe SARS-CoV-2 by increasing inflammation and reducing CD8 T-cell immunity, but its removal improves viral clearance and survival.

Aiolos restricts the generation of antigen-inexperienced, virtual memory CD8+ T cells

This study identifies Aiolos as a negative regulator of antigen-inexperienced, virtual memory CD8+ T cells, showing increased TVM cell numbers and function in its absence.

Faithful Modeling of Terminal CD8 T Cell Dysfunction and Epigenetic Stabilization In Vitro

This study develops an in vitro model of terminal CD8 T cell dysfunction and epigenetic stabilization, revealing stable exhaustion signatures and impaired functionality.

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer's disease

This study identifies DNA hypomethylation of CASP4 in AD microglia leading to increased CASP4 expression, which promotes neuroinflammation and amyloid-β deposition in Alzheimer's disease.