Mouse Fc-FcγRIV structure guides Fc engineering for cross-species FcγR recognition
Yakendra Bajgain, Mo Guo, Kelli M. Hager, Annalee W. Nguyen, Y Jessie Zhang, Jennifer A. Maynard
This paper determines the structure of mouse FcγRIV and uses it to engineer a human Fc variant that enhances cross-species FcγR recognition.
bioRxiv · May 15, 2026 · PreprintBiochemistry