Annalee W. Nguyen

The paper identifies a broadly neutralizing antibody targeting the S2 subunit of sarbecoviruses, revealing a conserved site of vulnerability in the spike protein.

This paper determines the structure of mouse FcγRIV and uses it to engineer a human Fc variant that enhances cross-species FcγR recognition.

The paper identifies antibodies that block PlGF or VEGFA interactions with NRP1, showing anti-proliferative effects in cancer cells and reduced angiogenesis.

This paper engineers IgG1 antibodies with modified Fc domains to resist viral Fc receptor binding, enhancing NK cell activation and reducing HCMV spread in infected cells.

This paper defines neutralizing epitopes on pertussis toxin using cryo-EM structures and functional assays, providing insights for vaccine development.