Fast-acting antidepressants trigger presynaptic BDNF release and structural plasticity at mouse mossy fiber-CA3 synapses
Irem L Atasoy-Rodriguez, Kenneth W. Johnson, Kishan Patel, Haroon Arain, Syed Zaidi, Karl F. Herold, Teresa A. Milner, Hugh C. Hemmings, Jimcy Platholi
This study shows fast-acting antidepressants like ketamine trigger BDNF release from presynaptic terminals in mouse hippocampal neurons, leading to structural plasticity in CA3 pyramidal neurons.
bioRxiv · Mar 2, 2026 · PreprintNeuroscience