Protein aggregation inhibitors induce divergent transcriptional responses in a cellular model of a-synuclein seeded aggregation
Paulien Van Minsel, Chris Van den Haute, Eline Vonck, Shirine Hentati, Michele Curcio, Xinran Song, Qian Yu, Matthias Versele, Kenneth W. Young, Patrick Chaltin, Bernard Thienpont, Veronique Daniëls, Veerle Baekelandt, Wouter Peelaerts
The paper evaluates three Syn aggregation inhibitors in a cellular model of a-synuclein aggregation using single-cell RNA sequencing to identify transcriptional changes and potential druggable pathways.
npj Parkinson s Disease · Aug 26, 2026Peer-reviewedNeuroscience