Chris Van den Haute

Protein aggregation inhibitors induce divergent transcriptional responses in a cellular model of a-synuclein seeded aggregation

The paper evaluates three Syn aggregation inhibitors in a cellular model of a-synuclein aggregation using single-cell RNA sequencing to identify transcriptional changes and potential druggable pathways.

A druggable ATP13A3-antizyme switch controls adaptive polyamine uptake in cancer

This study identifies ATP13A3-antizyme regulation as a mechanism for adaptive polyamine uptake in cancer, showing that targeting ATP13A3 with AMXT 1501 can block this response.

Development of convolutional neural networks for automated brain-wide histopathological analysis in mouse models of synucleinopathies

This paper develops CNNs for automated brain-wide histopathological analysis in mouse synucleinopathy models, enabling rapid, unbiased detection of neurodegeneration markers.

From injury to recovery: Functional neuronal regeneration after traumatic brain injury in the telencephalon of the young adult African turquoise killifish

This study investigates functional neuronal regeneration after traumatic brain injury in killifish, showing that new neurons integrate into circuits and enable behavioral recovery over 50 days.

Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits

This study shows that ATP10B loss causes dopaminergic neuron death and Parkinsonian symptoms in rats and human stem cell models.

The polyamine transporter ATP13A3 mediates DFMO-induced polyamine uptake in neuroblastoma

This study identifies ATP13A3 as a polyamine transporter mediating DFMO-induced polyamine uptake in neuroblastoma, highlighting it as a therapeutic target.

Functional characterization of ATP13A2 variants associated with distinct neurodegenerative disorders

The paper functionally characterizes ATP13A2 variants linked to neurodegenerative disorders, finding that only the homozygous NCL variant causes complete loss-of-function, while others show subtle defects.