Chiral shift toward D-serine reflects intrathecal inflammation in multiple sclerosis and counteracts motor impairment in a murine model
Alessandro Usiello, Kenta Arisumi, Tommaso Nuzzo, Luana Gilio, Sakiko Taniguchi, Rosita Russo, Haruhiko Motegi, Raffaella di Vito, Junichi Hata, Francesco Errico, Akinori Hashiguchi, Hideyuki Okano, Roberto Furlan, Annamaria Finardi, Mario Stampanoni Bassi, , Jumpei Sasabe
The paper shows that O_SCPLOWDC_SCPLOW-serine levels are elevated in MS patients and mitigates motor deficits in a murine model.
bioRxiv · May 7, 2025 · PreprintNeuroscience