Tommaso Nuzzo

Ultra-performance liquid chromatography-mass spectrometry analysis of post-mortem brain tissue reveals specific amino acid profile dysregulation in Parkinson's Disease and Alzheimer's Disease patients

This study uses UPLC-MS to analyze amino acid profiles in post-mortem brain tissue from PD and AD patients, revealing region-specific metabolic changes.

Deep Brain Stimulation rescues the homeostasis disruption of circulating D- and L-amino acids level in men with Parkinson's Disease

This study shows that Deep Brain Stimulation (STN-DBS) restores circulating D- and L-amino acid levels in male Parkinson's patients, unlike L-DOPA therapy, and suggests these amino acids as potential early biomarkers.

Chiral shift toward D-serine reflects intrathecal inflammation in multiple sclerosis and counteracts motor impairment in a murine model

The paper shows that O_SCPLOWDC_SCPLOW-serine levels are elevated in MS patients and mitigates motor deficits in a murine model.

Tandem Mass Tag-Based High-Resolution LC-MS/MS identifies free D-aspartate-induced expression of proteins linked to schizophrenia and autism spectrum disorder

The paper uses proteomic analysis to show D-aspartate depletion affects proteins linked to schizophrenia and autism spectrum disorder in mice.

Dysregulated balance of D- and L-amino acids modulating glutamatergic neurotransmission in severe spinal muscular atrophy.

The paper investigates amino acid metabolism in spinal muscular atrophy, finding dysregulated D- and L-amino acid levels linked to glutamatergic dysfunction and showing therapeutic potential with D-serine.