Alessandro Usiello

Embryonic depletion of D-aspartate perturbs NMDA receptor-dependent long-term potentiation in the hippocampus of juvenile mice

This study shows that embryonic depletion of D-aspartate in mice leads to increased NMDA receptor-dependent long-term potentiation in juvenile hippocampus, which is reversible with exogenous D-aspartate.

Ultra-performance liquid chromatography-mass spectrometry analysis of post-mortem brain tissue reveals specific amino acid profile dysregulation in Parkinson's Disease and Alzheimer's Disease patients

This study uses UPLC-MS to analyze amino acid profiles in post-mortem brain tissue from PD and AD patients, revealing region-specific metabolic changes.

Deep Brain Stimulation rescues the homeostasis disruption of circulating D- and L-amino acids level in men with Parkinson's Disease

This study shows that Deep Brain Stimulation (STN-DBS) restores circulating D- and L-amino acid levels in male Parkinson's patients, unlike L-DOPA therapy, and suggests these amino acids as potential early biomarkers.

Chiral shift toward D-serine reflects intrathecal inflammation in multiple sclerosis and counteracts motor impairment in a murine model

The paper shows that O_SCPLOWDC_SCPLOW-serine levels are elevated in MS patients and mitigates motor deficits in a murine model.

Tandem Mass Tag-Based High-Resolution LC-MS/MS identifies free D-aspartate-induced expression of proteins linked to schizophrenia and autism spectrum disorder

The paper uses proteomic analysis to show D-aspartate depletion affects proteins linked to schizophrenia and autism spectrum disorder in mice.

RNase H1 counteracts DNA damage and ameliorates SMN-dependent phenotypes in a Drosophila model of Spinal Muscular Atrophy

This study shows that RNase H1 reduces DNA damage and improves SMA-like symptoms in a Drosophila model by resolving RNA:DNA hybrids caused by SMN deficiency.

Dysregulated balance of D- and L-amino acids modulating glutamatergic neurotransmission in severe spinal muscular atrophy.

The paper investigates amino acid metabolism in spinal muscular atrophy, finding dysregulated D- and L-amino acid levels linked to glutamatergic dysfunction and showing therapeutic potential with D-serine.

The Mammalian Target of Rapamycin (mTOR) Kinase Mediates Haloperidol-Induced Cataleptic Behavior

This study shows that mTORC1 in the striatum prevents haloperidol-induced catalepsy, suggesting it could be a target for reducing antipsychotic side effects.

RasGRP1 (CalDAG-GEF-II) Mediates L-DOPA-induced Dyskinesia in a Mouse Model of Parkinson Disease

This study identifies RasGRP1 as a key mediator of L-DOPA-induced dyskinesia in a mouse model of Parkinson's disease, showing its role in multiple signaling pathways and potential as a therapeutic target.

Serotonin Buffers Hippocampal Neuroplasticity And Emotional Behavior

This study investigates how serotonin deficiency affects hippocampal neuroplasticity and emotional behavior in mice, revealing a buffering role of serotonin in adaptive responses to environmental stress.