Author

Jumpei Sasabe

Keio UniversityORCID 0000-0002-5093-2987Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Masato YasuiiD· 2 shared Sakiko Taniguchi· 2 shared Takanori Kanai∥iD· 2 shared Akinori HashiguchiiD· 1 shared Alessandro UsielloiD· 1 shared Amandine Papin· 1 shared Amit V. PateliD· 1 shared Angela ChamberyiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Masato YasuiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Chiral shift toward D-serine reflects intrathecal inflammation in multiple sclerosis and counteracts motor impairment in a murine model

Alessandro Usiello, Kenta Arisumi, Tommaso Nuzzo, Luana Gilio, Sakiko Taniguchi, Rosita Russo, Haruhiko Motegi, Raffaella di Vito, Junichi Hata, Francesco Errico, Akinori Hashiguchi, Hideyuki Okano, Roberto Furlan, Annamaria Finardi, Mario Stampanoni Bassi, , Jumpei Sasabe

The paper shows that O_SCPLOWDC_SCPLOW-serine levels are elevated in MS patients and mitigates motor deficits in a murine model.

bioRxiv · May 7, 2025 · PreprintNeuroscience

D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transport

Masataka Suzuki, Kenichiro Adachi, Pattama Wiriyasermukul, Mariko Fukumura, Ryota Tamura, Yoshinori Hirano, Yumi Aizawa, Tetsuya Miyamoto, Sakiko Taniguchi, Masahiro Toda, Hiroshi Homma, Kohsuke Kanekura, Kenji Yasuoka, Takanori Kanai∥, Masahiro Sugimoto, , Jumpei Sasabe

This study shows D-serine competes with mitochondrial L-serine transport, suppressing one-carbon metabolism and affecting neural cell proliferation.

bioRxiv · Sep 3, 2024 · PreprintBiochemistry

D-Serine agonism of GluN1-GluN3 NMDA receptors regulates the activity of enteric neurons and coordinates gut motility

Nancy Osorio, Magalie Martineau, Marina Fortea, Céline Rouget, Virginie Pénalba, Cindy J. Lee, Werend Boesmans, Malvyne Rolli‐Derkinderen, Amit V. Patel, Grégoire Mondielli, Sandrine Conrod, Vivien Labat-gest, Amandine Papin, Jumpei Sasabe, Jonathan V. Sweedler, , Jean‐Pierre Mothet

This study identifies D-serine and non-conventional GluN1-GluN3 NMDARs as regulators of enteric neuron activity and gut motility in mice and guinea-pigs.

bioRxiv · Apr 19, 2023 · PreprintNeuroscience