Author

Keqin Tan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:non-human primate· 1

Frequent Co-Authors

Huan CheniD· 2 shared Ye Bu· 2 shared Ying FaniD· 2 shared Danlan Qiu· 1 shared Guangping GaoiD· 1 shared Huapeng LiiD· 1 shared Huapeng LiiD· 1 shared Junlin CheniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Huan ChenORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Decoupling Efficacy from Toxicity: Engineering Spatial Control in AAV-Mediated Gene Therapy

Ying Fan, Keqin Tan, Huan Chen, Xiaoqu Chen, Yue Pan, Yajing Chen, Yangsiqi Ao, Ye Bu, Huapeng Li

This study shows that using tissue-specific AAV variants and local delivery reduces hepatic toxicity while maintaining therapeutic efficacy in gene therapy.

bioRxiv · Dec 26, 2025 · PreprintCancer Biology

Engineering novel AAV capsids by global de-targeting and subsequent muscle-specific tropism in mice and NHPs

Pan Yue, Yujian Zhong, Huan Chen, Youwei Zhang, Zhiyong Dai, Junlin Chen, Keqin Tan, X B Chen, Danlan Qiu, Longxiang Sheng, Xinping Tan, Ying Fan, Ye Bu, Zexin Zhou, Zhiming Yang, , Huapeng Li

The paper develops AAV.eM, a muscle-specific rAAV capsid with reduced off-target transduction, showing efficacy in Duchenne Muscular Dystrophy models and favorable safety in mice and NHPs.

bioRxiv · May 19, 2025 · PreprintBioengineering