Author

Ying Fan

ORCID 0009-0007-0545-932XUnclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Ying Fan2 papers · Huazhong Agricultural University

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:non-human primate· 1

Frequent Co-Authors

Huan CheniD· 2 shared Keqin Tan· 2 shared Ye Bu· 2 shared Danlan Qiu· 1 shared Guangping GaoiD· 1 shared Huapeng LiiD· 1 shared Huapeng LiiD· 1 shared Junlin CheniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Huan ChenORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 26, 2025

Decoupling Efficacy from Toxicity: Engineering Spatial Control in AAV-Mediated Gene Therapy

Ying Fan, Keqin Tan, Huan Chen…·Huapeng Li

This study shows that using tissue-specific AAV variants and local delivery reduces hepatic toxicity while maintaining therapeutic efficacy in gene therapy.

DOI 10.64898/2025.12.26.696588

mouseexperimental assay

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BioengineeringbioRxivPreprintMay 19, 2025

Engineering novel AAV capsids by global de-targeting and subsequent muscle-specific tropism in mice and NHPs

Pan Yue, Yujian Zhong, Huan Chen…·Huapeng Li

The paper develops AAV.eM, a muscle-specific rAAV capsid with reduced off-target transduction, showing efficacy in Duchenne Muscular Dystrophy models and favorable safety in mice and NHPs.

1 citation

mousenon-human primate

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