Encapsulated cell technology delivers ciliary neurotrophic factor to promote JAK/STAT-dependent photoreceptor survival in retinal degeneration
Yasuaki Iwama, Leia Laughlin, Sarah R. Harkins-Perry, Sarah Giles, Ava Maeyama, Kerstin Traxler, Mieke van Daelen, Roberto Bonelli, Kohji Nishida, Martin Friedlander, Marin L. Gantner, Kevin Eade
This study shows NT-501 reduces photoreceptor death in retinal models by CNTF-dependent JAK/STAT3 activation, establishing an optimal dose range for efficacy.
bioRxiv · Jul 30, 2026 · PreprintPharmacology & Toxicology