Author

Keshav Gaddam

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biochemistry· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Chuan Wu· 1 shared Enfu HuiiD· 1 shared George A. WeniD· 1 shared Haian Shao· 1 shared Takeya MasubuchiiD· 1 shared Xiaoxian Song· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiochemistry

Chuan Wu

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1 paper

Recent·Most cited

PD1-induced Shp2 condensation organizes inhibitory signalosomes through selective substrate partitioning

Takeya Masubuchi, George A. Wen, Xiaoxian Song, Keshav Gaddam, Haian Shao, Chuan Wu, Enfu Hui

This study shows that PD1-induced Shp2 phase separation forms dynamic condensates that organize inhibitory signaling by selectively partitioning substrates, thereby suppressing T cell activation.

bioRxiv · Mar 11, 2026 · PreprintBiochemistry