Author

George A. Wen

University of California San DiegoORCID 0009-0000-8732-5833Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Enfu HuiiD· 2 shared Takeya MasubuchiiD· 2 shared Christine Caron· 1 shared Chuan Wu· 1 shared Chuan WuiD· 1 shared Gerald P. MorrisiD· 1 shared Haian Shao· 1 shared Jack D. BuiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Enfu HuiORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMar 11, 2026

PD1-induced Shp2 condensation organizes inhibitory signalosomes through selective substrate partitioning

Takeya Masubuchi, George A. Wen, Xiaoxian Song…·Enfu Hui

This study shows that PD1-induced Shp2 phase separation forms dynamic condensates that organize inhibitory signaling by selectively partitioning substrates, thereby suppressing T cell activation.

DOI 10.64898/2026.03.09.710629

humanproteomics

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ImmunologyScience ImmunologyPeer-reviewedJan 3, 2025

Evolutionary fingerprint in rodent PD1 confers weakened activity and enhanced tumor immunity compared to human PD1

Takeya Masubuchi, Lin Chen, Nimi Marcel…·Enfu Hui

This study compares human and rodent PD1 proteins, finding rodent PD1 has weaker inhibitory activity and stronger tumor immunity due to evolutionary changes in Shp2 recruitment.

38 citationstop 1%

mousehuman

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