PD1-induced Shp2 condensation organizes inhibitory signalosomes through selective substrate partitioning
Takeya Masubuchi, George A. Wen, Xiaoxian Song, Keshav Gaddam, Haian Shao, Chuan Wu, Enfu Hui
This study shows that PD1-induced Shp2 phase separation forms dynamic condensates that organize inhibitory signaling by selectively partitioning substrates, thereby suppressing T cell activation.
bioRxiv · Mar 11, 2026 · PreprintBiochemistry