IgG autoantibodies in bullous pemphigoid directly induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes:
Lei Bao, Christian Fernando Guerrero‐Juarez, Jing Li, Manuela Pigors, Shirin Emtenani, Yingzi Liu, Adrian Pablo Mansini, Yulu F. Wang, Aadil Ahmed, Norito Ishii, Takashi Hashimoto, Bethany E. Perez White, Stefan J. Green, Kevin Kunstman, Nicole C. Nowak, , Kyle T. Amber
This study shows that BP-IgG autoantibodies induce a pro-inflammatory response in keratinocytes via MyD88-dependent signaling, contributing to BP pathology.
Nature Communications · Aug 6, 2025Peer-reviewedImmunology