Resistance of mitochondrial DNA to chemical-induced germline mutations is independent of mitophagy in C. elegans
Tess C. Leuthner, Laura Benzing, Brendan F. Kohrn, Christina M. Bergemann, Michael J. Hipp, Kathleen A. Hershberger, Danielle Ferraz Mello, Tymofii Sokolskyi, Kevin Stevenson, Ilaria R Merutka, Sarah A. Seay, Simon G. Gregory, Scott R. Kennedy, Joel N. Meyer
This study investigates the effects of cadmium and Aflatoxin B1 on mtDNA mutagenesis in C. elegans, finding no effect on mutation frequency or spectrum despite mitophagy defects.
Nucleic Acids Research · Aug 10, 2022Peer-reviewedGenomics