Simon G. Gregory

The paper evaluates four non-formalin fixed scRNA-seq assays across multiple metrics to identify their strengths and limitations for different experimental goals.

This study uses multi-region spatial transcriptomics to identify region-specific transcriptional responses to Aβ plaques in AD, revealing differences in neuronal vulnerability and molecular pathways.

This paper develops a mouse model of HER2-positive breast cancer cerebellar metastases and identifies IL34-induced Arg1+ macrophages as key drivers of tumor growth, showing that targeting CSF1R can reduce metastases.

This study links accelerated epigenetic age (GrimAge) to white matter degeneration in the human brain using diffusion MRI and longitudinal data.

The paper shows that inhibiting UBE2N in Tregs enhances anti-tumor immunity without causing autoimmunity by converting Tregs into effector-like cells.

This study identifies a neurovascular progenitor cell type in glioblastoma that links distinct malignant lineages and influences tumor composition and survival.

This study identifies ASD-like transcriptomic changes in oligodendrocytes and microglia of C58/J mice amygdala, dependent on sex and sociability, using bulk RNA-Seq and snRNA-Seq.

This study identifies DDX39B as a regulator of FOXP3 RNA splicing, which influences T regulatory cell fate and immune tolerance, linking it to multiple sclerosis risk.

The paper identifies a nonsynonymous ERAP1 variant associated with increased susceptibility to influenza virus using scHi-HOST, a single-cell method for genetic susceptibility testing.

This study investigates the effects of cadmium and Aflatoxin B1 on mtDNA mutagenesis in C. elegans, finding no effect on mutation frequency or spectrum despite mitophagy defects.