A Novel Drosophila Model of Cancer Cachexia Reveals Conserved Jak/Stat Dependent Glucagon-like Akh Activation as a Driver of Metabolic Reprogramming and Systemic Wasting
Kewei Yu, Gurpreet S. Moroak, Esther M. Verheyen
This study establishes a Drosophila model of cancer cachexia and identifies a conserved Jak/Stat-Akh signaling pathway driving metabolic reprogramming and systemic wasting.
bioRxiv · Sep 10, 2025 · PreprintCancer Biology