Spatially resolved, multimodal in vivo Perturb-seq using antibody-based cell hashing
Alexander A. Nevue, George C. Hartoularos, Cynthia del Valle, Kheerthivasan Ramachandran, Jerika J. Barron, Maria Erendira Calleja Cervantes, Hannah Lee, Joseph S. Bowness, Lars Velten, Chiara Ricci-Tam, Maayan Levy, Alexander Dobin, Chun Ye, Inna Averbukh, David Lara‐Astiaso
This paper introduces PerturbSpace, a method combining CRISPR perturbations with spatially hashed single-cell multiomics to study gene function in tissue architecture.
bioRxiv · May 26, 2026 · PreprintGenomics