Author

Cynthia del Valle

Arc Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

David Lara‐AstiasoiD· 3 shared Nikolaus FortelnyiD· 2 shared Wolfgang Esser‐SkalaiD· 2 shared Aarathy Ravi Sundar Jose GeethaiD· 1 shared Ainhoa Goñi‐SalaverriiD· 1 shared Alexander A. NevueiD· 1 shared Alexander DobiniD· 1 shared Anna Rosaria de Vito· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

David Lara‐AstiasoORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Spatially resolved, multimodal in vivo Perturb-seq using antibody-based cell hashing

Alexander A. Nevue, George C. Hartoularos, Cynthia del Valle, Kheerthivasan Ramachandran, Jerika J. Barron, Maria Erendira Calleja Cervantes, Hannah Lee, Joseph S. Bowness, Lars Velten, Chiara Ricci-Tam, Maayan Levy, Alexander Dobin, Chun Ye, Inna Averbukh, David Lara‐Astiaso

This paper introduces PerturbSpace, a method combining CRISPR perturbations with spatially hashed single-cell multiomics to study gene function in tissue architecture.

bioRxiv · May 26, 2026 · PreprintGenomics

Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens

Laura Pilar Aguado‐Alvaro, Nerea Garitano, Wolfgang Esser‐Skala, Judith R. Sayers, Cynthia del Valle, Daniel Alameda, Julen Mendieta-Esteban, María Eréndira Calleja-Cervantes, Ainhoa Goñi‐Salaverri, Jon Zazpe, Anna Rosaria de Vito, Francesco P. Marchese, Diego Alignani, Juliana Cudini, Torsten Groß, , David Lara‐Astiaso

The paper identifies epigenetic regulators of fibrotic transformation in cardiac fibroblasts using bulk and single-cell CRISPR screens and shows KAT5 inhibition reduces fibrotic responses in human fibroblasts.

Nature Communications · Nov 26, 2025Peer-reviewedCell Biology

Differences between in vivo and ex vivo models drive divergent perturbation outcomes

Aarathy Ravi Sundar Jose Geetha, Cynthia del Valle, Wolfgang Esser‐Skala, David Lara‐Astiaso, Nikolaus Fortelny

The paper compares perturbation outcomes in in vivo and ex vivo hematopoietic stem cell models, finding systematic biases and challenges in predicting in vivo effects from ex vivo data.

bioRxiv · Sep 2, 2025 · PreprintSystems Biology