Corticospinal propagation of full-length TDP-43 toxicity drives brain-to-muscle pathology
Jacopo Marongiu, V. Crippa, Isabella Marzi, Clara Porcedda, Maria Cristina Gagliani, Annalisa Brivio, Maria Francesca Palmas, Michela Etzi, Marcello Serra, Khosro Aminzadeh, Maria Antonietta Casu, Ignazia Mocci, Augusta Pisanu, Nicola Simola, Valeria Sogos, , Anna Rosa Carta
This study shows that full-length TDP-43 spreads from the brain to muscle in rats, causing pathology and dysfunction.
bioRxiv · Mar 30, 2026 · PreprintNeuroscience