A novel multicellular model of the adult mouse sinoatrial node retains spontaneous electrical activity and enables live investigation of the S100B-associated cell population
Georgiana Luisa Baca, Robert E. Monticone, Bruce D. Ziman, Shah Md Toufiqur Rahman, Pathik Parekh, Sadia Afrin, Christopher Dunn, Richard S. Telljohann, Dongmei Yang, Kwan-Wood Gabriel Lam, Peter Killeen, Dimitrios Tsitsipatis, Ana‐Maria Zăgrean, Myong‐Hee Sung, Nigel H. Greig, , Edward G. Lakatta
Dissociated adult mouse sinoatrial node cultures stay spontaneously electrically active beyond ten days on MEA arrays and, on compliant hydrogels, permit live tracking of heterogeneous S100B-EGFP-labeled cells.
bioRxiv · Jul 20, 2026 · PreprintCell Biology✦ In-depth digest