Alfonso De Simone

This study shows α-synuclein modulates spontaneous dopamine release via calcium and phosphorylation-dependent mechanisms, independent of full-fusion recycling.

This study shows that full-length TDP-43 spreads from the brain to muscle in rats, causing pathology and dysfunction.

This paper evaluates 3MP, a novel immunomodulator, showing it reduces alpha-Synuclein aggregation and microglial inflammation in vitro and in vivo, offering a dual-target therapeutic approach for Parkinson's disease.

This paper introduces Martini3-NMR, a framework that integrates NMR data into coarse-grained simulations to improve the accuracy of protein conformational ensembles.

This study introduces NapshiftC, a neural network that uses NMR chemical shifts to improve coarse-grained simulations of intrinsically disordered proteins by incorporating secondary structure.

This study shows that 24S-HC and 27-HC, brain cholesterol metabolites, cause neuronal dysfunction in human iPSC-derived neurons by disrupting calcium signaling, organelle function, and alpha-synuclein accumulation.

This study investigates how Ca2+ and Na+ ions affect alpha-synuclein aggregation and fibril polymorphism, revealing their distinct roles in modulating conformational dynamics and structural outcomes.

This study shows that nitration of alpha-synuclein after fibrillization reduces its seeding activity and pathology formation in neurons and in vivo.

The paper develops a unified in vitro to in vivo fluorescence lifetime screening platform to identify amyloid β aggregation inhibitors, revealing a new compound effective in multiple models.

This paper develops NMR methods to measure residual dipolar couplings in the ribosome's dynamic regions, refining structural models and validating them with experimental data.