Author

David Tweedie

National Institutes of HealthORCID 0000-0002-8446-4544Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Nigel H. GreigiD· 2 shared Alfonso De SimoneiD· 1 shared Anna Rosa CartaiD· 1 shared Ari W. SchaleriD· 1 shared Augusta PisanuiD· 1 shared Clara PorceddaiD· 1 shared Daniel R. SabaniD· 1 shared Daniel T. GrayiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Nigel H. GreigORCID

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3 papers

Recent·Most cited

A new therapeutic approach for Parkinson's disease: dual targeting of alpha-Synuclein aggregation and microglial function by the novel immunomodulator 3-Monothiopomalidomide

Maria Francesca Palmas, Khosro Aminzadeh, Matteo Runfola, Pathik Parekh, Clara Porcedda, David Tweedie, Luca Casula, Maria Cristina Cardia, Jacopo Marongiu, Michela Etzi, Francesco Lai, Marcello Serra, Augusta Pisanu, Valeria Sogos, Alfonso De Simone, , Anna Rosa Carta

This paper evaluates 3MP, a novel immunomodulator, showing it reduces alpha-Synuclein aggregation and microglial inflammation in vitro and in vivo, offering a dual-target therapeutic approach for Parkinson's disease.

bioRxiv · Mar 30, 2026 · PreprintNeuroscience

Anti-inflammatory and pro-proliferative effects of fasudil in human trisomy 21 neural progenitor cells

Laura L. Baxter, Sarah E. Lee, Kevin A. Fuentes, Iman A Mosley, Jonathan D. Raymond, Fayçal Guedj, Di Zhou, Donna K. Slonim, Elliot J. Glotfelty, David Tweedie, Nigel H. Grieg, Diana W. Bianchi

This study evaluates fasudil's effects on trisomy 21 neural progenitor cells, showing increased proliferation and reduced inflammation.

bioRxiv · Mar 20, 2026 · PreprintPharmacology & Toxicology

Microglia drive pockets of neuroinflammation in middle age

Eric N. Moca, Daniela Lecca, Keenan T. Hope, Fanny Etienne, Ari W. Schaler, Katherine Espinoza, Megan S. Chappell, Daniel T. Gray, David Tweedie, Shanaya Sidhu, Lindsay Masukawa, Hannah Sitoy, Rose Mathew, Daniel R. Saban, Nigel H. Greig, Lindsay M. De Biase

The paper shows that microglia in specific brain regions exhibit premature aging-related inflammation in middle age, which may affect nearby neurons.

Journal of Neuroscience · Apr 8, 2022Peer-reviewedNeuroscience