Author

Jacopo Marongiu

University of Cagliari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:rat· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Alfonso De SimoneiD· 2 shared Anna Rosa CartaiD· 2 shared Augusta PisanuiD· 2 shared Clara PorceddaiD· 2 shared Khosro Aminzadeh· 2 shared Marcello SerraiD· 2 shared Maria Francesca PalmasiD· 2 shared Michela Etzi· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Alfonso De SimoneORCID

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3 papers

Recent·Most cited

Alpha-synuclein and neuromelanin converge to promote Parkinsons disease pathology

Alba Nicolau, Marta González-Sepúlveda, Joana M. Cladera-Sastre, Thais Cuadros, Annabelle Parent, Gerard Roch, Jacopo Marongiu, Benjamin Huynh, Anahid Ansari Mahabadian, Feifei Su, Zac Chatterton, Javier Hoyo, Ariadna Laguna, YuHong Fu, Glenda Margaret Halliday, Miquel Vila

This study identifies a bidirectional pathogenic relationship between alpha-synuclein and neuromelanin in Parkinson's disease, showing they promote each other's accumulation and neuronal loss.

bioRxiv · Oct 24, 2026 · PreprintNeuroscience

Corticospinal propagation of full-length TDP-43 toxicity drives brain-to-muscle pathology

Jacopo Marongiu, V. Crippa, Isabella Marzi, Clara Porcedda, Maria Cristina Gagliani, Annalisa Brivio, Maria Francesca Palmas, Michela Etzi, Marcello Serra, Khosro Aminzadeh, Maria Antonietta Casu, Ignazia Mocci, Augusta Pisanu, Nicola Simola, Valeria Sogos, , Anna Rosa Carta

This study shows that full-length TDP-43 spreads from the brain to muscle in rats, causing pathology and dysfunction.

bioRxiv · Mar 30, 2026 · PreprintNeuroscience

A new therapeutic approach for Parkinson's disease: dual targeting of alpha-Synuclein aggregation and microglial function by the novel immunomodulator 3-Monothiopomalidomide

Maria Francesca Palmas, Khosro Aminzadeh, Matteo Runfola, Pathik Parekh, Clara Porcedda, David Tweedie, Luca Casula, Maria Cristina Cardia, Jacopo Marongiu, Michela Etzi, Francesco Lai, Marcello Serra, Augusta Pisanu, Valeria Sogos, Alfonso De Simone, , Anna Rosa Carta

This paper evaluates 3MP, a novel immunomodulator, showing it reduces alpha-Synuclein aggregation and microglial inflammation in vitro and in vivo, offering a dual-target therapeutic approach for Parkinson's disease.

bioRxiv · Mar 30, 2026 · PreprintNeuroscience