Modeling Fibrosis with MASH Patient Liver-Derived Organoids.
Andy Liu, A. Dylan T. Haseman, Khushal Bantu, Jia Nong, Vladimir R. Muzykantov, Jilian R. Melamed, Michael Kegel, Jenna Muscat-Rivera, Drew Weissman, David L Smith, Mei Zhang, Daniel James Rader, Tobias D. Raabe
The paper develops a 3D MASH liver fibrosis model using patient-derived organoids and shows that YAP1 knockdown reduces fibrosis by inducing myofibroblast senescence.
bioRxiv · Sep 18, 2025 · PreprintBioengineering