BioengineeringAdvanced MaterialsPeer-reviewed
High-throughput in vivo screening using barcoded mRNA identifies lipid nanoparticles with extrahepatic tropism for cancer immunotherapy
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu…·Michael J. Mitchell
Author
Jilian R. Melamed
University of PennsylvaniaORCID 0000-0003-0364-9334Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2025-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 28 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship4 papers
Recent·Most cited
- BioengineeringbioRxivPreprint
Anionic lipids modulate mRNA-lipid nanoparticle immunogenicity and confer protection in a mouse model of multiple sclerosis
Jilian R. Melamed, Jenna Muscat-Rivera, Michael Kegel…·Drew Weissman
This study shows that anionic lipids in mRNA-LNPs can modulate immune responses, reducing inflammation and disease in a multiple sclerosis mouse model.
5 citations - Cancer BiologyCarcinogenesisPeer-reviewed
SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer
Shinji Nakamichi, Natalia von Muhlinen, Leo Yamada…·Curtis C. Harris
This study shows that knocking down SRSF3 induces cellular senescence in NSCLC cells, including those without targetable mutations, suggesting a potential new therapeutic strategy.
4 citations - BioengineeringbioRxivPreprint
Modeling Fibrosis with MASH Patient Liver-Derived Organoids.
Andy Liu, A. Dylan T. Haseman, Khushal Bantu…·Tobias D. Raabe
The paper develops a 3D MASH liver fibrosis model using patient-derived organoids and shows that YAP1 knockdown reduces fibrosis by inducing myofibroblast senescence.