Neutrophils exposed to a cholesterol metabolite secrete extracellular vesicles that promote epithelial-mesenchymal transition and stemness in breast cancer cells.
Natalia Krawczyńska, Yu Wang, Ki Lim, Anasuya Das Gupta, Ralph John Emerson J. Molino, Adam Lenczowski, Marwan Abughazaleh, Shruti V. Bendre, Yifan Fei, Hannah Kim, Lara I. Kockaya, Claire P. Schane, Dhanya Pradeep, Desirée Rodriguez-Casiano, Alvaro Gonzalo Hernandez, , Erik Russell Nelson
This study shows that 27HC-treated neutrophils release sEVs that induce EMT and stemness in breast cancer cells via WNT/β-catenin pathway activation.
Cancer Letters · Oct 29, 2025Peer-reviewedCancer Biology