Neutrophils exposed to a cholesterol metabolite secrete extracellular vesicles that promote epithelial-mesenchymal transition and stemness in breast cancer cells.
Natalia Krawczyńska, Yu Wang, Ki Lim…·Erik Russell Nelson
This study shows that 27HC-treated neutrophils release sEVs that induce EMT and stemness in breast cancer cells via WNT/β-catenin pathway activation.