Dhanya Pradeep

Loss of Mast cells and histaminergic signaling link diet to platelet-mediated NETosis and mammary cancer recurrence

This study links diet to mammary cancer recurrence via mast cell loss and histaminergic signaling, showing that H2R antagonists promote platelet-mediated NETosis and reemergence from dormancy.

Cholesterol efflux protein, ABCA1, supports anti-cancer functions of myeloid immune cells

This study identifies ABCA1 as a cholesterol efflux protein that enhances anti-cancer functions of myeloid cells, with clinical relevance in breast tumors.

Neutrophils exposed to a cholesterol metabolite secrete extracellular vesicles that promote epithelial-mesenchymal transition and stemness in breast cancer cells.

This study shows that 27HC-treated neutrophils release sEVs that induce EMT and stemness in breast cancer cells via WNT/β-catenin pathway activation.

The JAW-TCP-FUL genetic axis triggers an early reorientation of cell anisotropy to initiate and drive fertilization-dependent fruit elongation in Arabidopsis

The paper identifies a genetic axis involving JAW-TCP and FUL that drives fertilization-dependent fruit elongation by reorienting cell anisotropy in Arabidopsis.

Cholesterol Metabolite 27-Hydroxycholesterol Enhances the Secretion of Cancer Promoting Extracellular Vesicles by a Mitochondrial ROS-Induced Impairment of Lysosomal Function

This study shows that 27-hydroxycholesterol increases EV secretion by impairing lysosomal function through mitochondrial ROS, and antioxidant treatment reverses this effect.