VE-cadherin NOT-gated CD93 CAR T cells discriminate between AML and healthy endothelial cells
Tess Woodring, Otto A. Kletzien, Kierstin Schlevensky, Cristina Sánchez‐de‐Diego, Paresh Vishwasrao, Lauren Mahoney, Sheena C. Kerr, Rebecca M. Richards
This paper develops NOT-gated CAR T cells targeting CD93 and VE-cadherin to reduce off-tumor toxicity against endothelial cells while maintaining antileukemic activity in AML.
bioRxiv · Mar 11, 2026 · PreprintImmunology