Lauren Mahoney

This study shows that blocking the interferon-gamma axis reduces CAR T cell effectiveness against AML by impairing antigen expression and cytotoxicity, suggesting caution with IFN-gamma inhibitors in AML treatment.

This study expands and activates allogeneic canine NK cells ex vivo, demonstrating their safety and in vitro potency for treating metastatic solid tumors.

This paper develops NOT-gated CAR T cells targeting CD93 and VE-cadherin to reduce off-tumor toxicity against endothelial cells while maintaining antileukemic activity in AML.

This study measures piconewton forces transmitted by CARs during antigen engagement, showing co-stimulatory domains are essential for force generation and early signaling.