Otto A. Kletzien

This study shows that blocking the interferon-gamma axis reduces CAR T cell effectiveness against AML by impairing antigen expression and cytotoxicity, suggesting caution with IFN-gamma inhibitors in AML treatment.

This paper develops NOT-gated CAR T cells targeting CD93 and VE-cadherin to reduce off-tumor toxicity against endothelial cells while maintaining antileukemic activity in AML.

This study shows that the RNA-binding selectivity of hnRNP U's RGG/RG motifs is reduced by the disordered region, leading to broad RNA interactions.