Sheena C. Kerr

Rhinovirus Infection of Human Airway Epithelial Cells Stimulates Neutrophil Superoxide

This study shows that rhinovirus does not directly activate neutrophils but instead induces epithelial release of factors that enhance neutrophil migration and apical debris that triggers ROS production.

Lymphatic endothelial cells regulate neutrophil phenotypes and function in a microphysiological model of infection

This study shows lymphatic endothelial cells influence neutrophil migration, phagocytosis, and NETosis in a 3D infection model, with differential effects based on bacterial type.

Exclusive liquid repellency isolation (ELRi) microliter scale isolation technique unmasks T-cell migration defects to CCL21 in pediatric asthma

ELRi isolates immune cells from small blood samples, revealing impaired T-cell migration to CCL21 in pediatric asthma.

CXCL13-CXCR5 Signaling in CD8⁺ T Cell Recruitment and Lymphoid Immune Organization in Clear Cell Renal Cell Carcinoma

This study identifies CXCL13-CXCR5 signaling as critical for CD8 T cell recruitment and immune organization in ccRCC, with potential as a biomarker and therapeutic target.

A Head and Neck Cancer Patient-Specific Microphysiological System for Predicting Response to Chemoradiation

This paper develops a patient-specific microphysiological system to predict chemoradiation response in head and neck cancer by reconstructing tumor microenvironment complexity.

VE-cadherin NOT-gated CD93 CAR T cells discriminate between AML and healthy endothelial cells

This paper develops NOT-gated CAR T cells targeting CD93 and VE-cadherin to reduce off-tumor toxicity against endothelial cells while maintaining antileukemic activity in AML.

A microphysiological system of sterile injury demonstrates neutrophil reverse migration via macrophage-derived extracellular vesicle crosstalk.

This paper develops a human microphysiological system to study neutrophil reverse migration mediated by macrophage-derived extracellular vesicles in sterile injury.