Glycoengineering of the hepatitis C virus E2 glycoprotein leads to improved biochemical properties and enhanced immunogenicity
Liudmila Kulakova, Kiki H. Li, Austin W.T. Chiang, Michael P. Schwoerer, Sanne Schoffelen, Khadija H. Elkholy, Kinlin L. Chao, Salman Shahid, Bhoj Kumar, Nathan B. Murray, Stephanie A. Archer‐Hartmann, Parastoo Azadi, Bjørn Gunnar Rude Voldborg, Alexander Marin, Roy A. Mariuzza, , Thomas R. Fuerst
This study shows that glycoengineering of HCV E2 glycoprotein affects antigen biochemical properties and immune response, with some glycans improving neutralization potency.
bioRxiv · Apr 2, 2025 · PreprintImmunology