Identification of clofibric acid as a SYVN1 ligand for PROTAC development
Warren, Julia, MD, PhD, Anandarao Munakala, Keith D. Zientek, Kilsun Kim, Phillip A. Wilmarth, Ashok P. Reddy, Bingbing X. Li, Xiangshu Xiao
This paper identifies clofibric acid as a SYVN1 ligand and demonstrates its use in developing SYVN1-dependent BRD4 PROTACs with improved degradation efficiency.
bioRxiv · Jan 28, 2026 · PreprintPharmacology & Toxicology